Group Leader in the MRC Laboratory of Molecular Biology
Departments and Institutes
The wealth of genome-scale data now available for sequences, structures and interactions provides an unprecedented opportunity to systematically investigate principles of gene and protein interactions. We are particularly interested in the evolution and dynamics of regulatory and physical interaction networks. To address these questions, we combine computational and mathematical approaches with both genome-wide and individual gene/protein experiments.
Our lab focuses on two main areas:
(1) transcription factors and the regulation of gene expression
(2) physical protein-protein interactions and protein complexes.